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Mania paroxetine may cause symptoms of mania to worsen or return.

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AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.

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Concomitant use or within 14 days of MAOIs increases risk of serotonin syndrome Reactions to concomitant administration with MAOIs include tremormyoclonusdiaphoresisnauseavomitingflushingdizzinesshyperthermia with features resembling neuroleptic malignant syndromeseizuresrigidityautonomic instability with possible rapid fluctuations of vital signsand mental status changes that include extreme agitation progressing to delirium and coma Starting paroxetine in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue SSRI immediately and monitor for CNS toxicitymay resume 24 hr after last linezolid or methylene blue doseor after 2 weeks of monitoring5 weeks for fluoxetinewhichever comes first.

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paroxetine potently and selectively inhibits neuronal serotonin reuptake through antagonism of the serotonin transporter.

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